Valuation: Silence Therapeutics plc

Market Cap 433M 573M 512M 476M 817M 55.47B 821M 5.73B 2.24B 28.25B 2.15B 2.11B 90.75B P/E 2026 *
-18.5x
P/E 2027 * -14.9x
Enterprise Value 300M 397M 354M 330M 566M 38.43B 569M 3.97B 1.55B 19.57B 1.49B 1.46B 62.86B EV / Sales 2026 *
931x
EV / Sales 2027 * 345x
Free-Float
69.35%
Yield 2026 *
-
Yield 2027 * -
Manager TitleAgeSince
Chief Executive Officer 72 01/12/2025
Director of Finance/CFO 54 01/02/2022
Chief Tech/Sci/R&D Officer - 01/01/2021
Director TitleAgeSince
Director/Board Member 63 21/06/2018
Chairman 72 01/01/2004
Director/Board Member 65 05/05/2025
Change 5-day change 1-year change 3-year change Capi.($)
-2.59%-5.70%+40.86%+83.11% 72.13B
+3.23%-13.45%+6.00%+55.77% 49.41B
+1.56%+2.07%+5.03%+33.38% 47.24B
+0.87%-7.83%+296.82%+657.83% 40.32B
+0.39%-0.32%+29.55%+30.83% 42.61B
+1.24%-1.20%+0.96%+103.86% 39.81B
-2.13%-2.18%+7.51%+50.31% 30.52B
+5.32%+0.11%-8.77%-12.81% 23.13B
+3.78%+5.71%+16.43%-1.77% 21.09B
Average +1.33%-3.91%+43.82%+111.17% 40.7B
Weighted average by Cap. +0.81%-4.28%+46.74%+118.77%

Financials

2026 *2027 *
Net sales 322K 427K 381K 354K 608K 41.29M 611K 4.26M 1.67M 21.03M 1.6M 1.57M 67.55M 751K 993K 887K 824K 1.42M 96.11M 1.42M 9.93M 3.88M 48.96M 3.73M 3.65M 157M
Net income -42.14M -55.77M -49.77M -46.28M -79.5M -5.4B -79.84M -557M -218M -2.75B -209M -205M -8.83B -71.01M -93.99M -83.88M -77.99M -134M -9.09B -135M -939M -367M -4.63B -353M -345M -14.88B
Net Debt -133M -176M -157M -146M -251M -17.04B -252M -1.76B -689M -8.68B -661M -647M -27.88B -174M -230M -206M -191M -328M -22.29B -330M -2.3B -901M -11.35B -864M -846M -36.46B
Logo Silence Therapeutics plc
Silence Therapeutics plc is a global clinical-stage biotechnology company engaged in transforming people’s lives by silencing diseases through precision-engineered medicines created with proprietary siRNA (short interfering RNA) technology. The Company leverages its mRNAi GOLD platform to create siRNAs designed to precisely target and silence disease-associated genes in the liver. The Company focuses on areas of high unmet medical need with programs advancing cardiovascular disease, hematology and rare diseases. Divesiran (SLN124) is its wholly owned siRNA product candidate designed to inhibit TMPRSS6 expression in the liver. Zerlasiran is a siRNA molecule designed for the treatment of cardiovascular disease associated with elevated Lp(a), a lipoprotein in the blood. In addition to its wholly owned clinical pipeline, it has a third siRNA product candidate from its mRNAi GOLD platform in Phase I development in an undisclosed indication through its collaboration with AstraZeneca.
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ESG MSCI
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Ratings Surperformance© - Silence Therapeutics plc