Valuation: Silence Therapeutics plc

Market Cap 367M 490M 429M 394M 697M 46.69B 707M 4.73B 1.84B 22.95B 1.84B 1.8B 79.09B P/E 2026 *
-17.4x
P/E 2027 * -15.5x
Enterprise Value 221M 295M 258M 237M 419M 28.07B 425M 2.84B 1.11B 13.8B 1.11B 1.08B 47.55B EV / Sales 2026 *
88.5x
EV / Sales 2027 * 34.2x
Free-Float
69.36%
Yield 2026 *
-
Yield 2027 * -
1 day-1.05%
1 week+2.47%
Current month-5.37%
1 month+51.68%
3 months+74.92%
6 months+68.94%
Current year+70.89%
1 week 9.96
Extreme 9.96
11.06
1 month 5.88
Extreme 5.88
11.06
Current year 4.19
Extreme 4.19
11.06
1 year 4.19
Extreme 4.19
11.06
3 years 1.97
Extreme 1.97
27.72
5 years 1.97
Extreme 1.97
27.72
10 years 1.97
Extreme 1.97
35
Manager TitleAgeSince
Chief Executive Officer 72 14/12/2025
Director of Finance/CFO 54 21/02/2022
Chief Tech/Sci/R&D Officer - 01/01/2021
Director TitleAgeSince
Director/Board Member 63 21/06/2018
Chairman 72 01/12/2019
Director/Board Member 54 18/12/2025
Date Insider Type Main position Quantity % Market Cap.
01-02Free

Director

90,000 0.0635%
01-02Free

Chief Technology Officer

300,000 0.2117%
01-02Free

Chief Financial Officer

375,000 0.2646%
Change 5-day change 1-year change 3-year change Capi.($)
-1.05%+2.47%+88.22%+74.62% 491M
+1.70%+7.41%+2.50%+8.22% 49.92B
+0.92%+3.93%+399.71%+605.33% 40.23B
+1.89%+8.32%+26.06%-6.35% 34.55B
+2.38%+6.35%+21.25%+64.58% 33.09B
+3.96%+10.67%+8.30%+40.44% 27.51B
+2.51%+5.27% - - 17.05B
+2.58%+5.79%+73.44%+133.27% 15.92B
+0.32%+0.58%+14.00%+19.59% 13.86B
+3.30%+0.76%+90.23%+99.12% 13.52B
Average +1.85%+5.63%+80.41%+115.42% 24.62B
Weighted average by Cap. +2.06%+6.53%+90.20%+137.77%

Financials

2026 *2027 *
Net sales 2.5M 3.33M 2.91M 2.68M 4.73M 317M 4.8M 32.14M 12.49M 156M 12.51M 12.24M 537M 3.44M 4.59M 4.02M 3.69M 6.53M 437M 6.63M 44.32M 17.23M 215M 17.25M 16.88M 741M
Net income -50.34M -67.22M -58.77M -54.01M -95.48M -6.4B -96.93M -648M -252M -3.15B -252M -247M -10.84B -84.67M -113M -98.84M -90.83M -161M -10.77B -163M -1.09B -424M -5.29B -424M -415M -18.23B
Net Debt -146M -196M -171M -157M -278M -18.62B -282M -1.89B -733M -9.15B -734M -718M -31.54B -249M -333M -291M -268M -473M -31.71B -480M -3.21B -1.25B -15.59B -1.25B -1.22B -53.72B
Logo Silence Therapeutics plc
Silence Therapeutics plc is a global clinical-stage biotechnology company engaged in transforming people’s lives by silencing diseases through precision-engineered medicines created with proprietary siRNA (short interfering RNA) technology. The Company leverages its mRNAi GOLD platform to create siRNAs designed to precisely target and silence disease-associated genes in the liver. The Company focuses on areas of high unmet medical need with programs advancing cardiovascular disease, hematology and rare diseases. Divesiran (SLN124) is its wholly owned siRNA product candidate designed to inhibit TMPRSS6 expression in the liver. Zerlasiran is a siRNA molecule designed for the treatment of cardiovascular disease associated with elevated Lp(a), a lipoprotein in the blood. In addition to its wholly owned clinical pipeline, it has a third siRNA product candidate from its mRNAi GOLD platform in Phase I development in an undisclosed indication through its collaboration with AstraZeneca.
Employees
88
Date Price Change Volume
02/07/26 $10.39 -1.05% 696,727
01/07/26 $10.50 -4.37% 718,986
30/06/26 $10.98 +1.76% 556,751
29/06/26 $10.79 +6.41% 1,151,446
26/06/26 $10.14 +1.40% 1,080,895
Trader
Investor
-
Global
-
Quality
-
ESG MSCI
-
Sell
Consensus
Buy
Mean consensus
BUY
Number of Analysts
7
Last Close Price
10.39USD
Average target price
29.17USD
Spread / Average Target
+180.72%

Quarterly revenue - Rate of surprise