Valuation: Silence Therapeutics plc

Market Cap 328M 439M 384M 355M 618M 42.21B 629M 4.23B 1.66B 20.67B 1.65B 1.61B 71.17B P/E 2026 *
-15.5x
P/E 2027 * -13.8x
Enterprise Value 182M 243M 213M 197M 342M 23.36B 348M 2.34B 919M 11.44B 914M 893M 39.39B EV / Sales 2026 *
72.8x
EV / Sales 2027 * 22.8x
Free-Float
69.36%
Yield 2026 *
-
Yield 2027 * -
1 day+2.37%
1 week-6.11%
Current month-13.21%
1 month+36.14%
3 months+55.72%
6 months+62.35%
Current year+56.74%
1 week 8.91
Extreme 8.91
10.42
1 month 6.52
Extreme 6.52
11.06
Current year 4.19
Extreme 4.19
11.06
1 year 4.19
Extreme 4.19
11.06
3 years 1.97
Extreme 1.97
27.72
5 years 1.97
Extreme 1.97
27.72
10 years 1.97
Extreme 1.97
35
Manager TitleAgeSince
Chief Executive Officer 72 01/12/2025
Director of Finance/CFO 54 01/02/2022
Chief Tech/Sci/R&D Officer - 01/01/2021
Director TitleAgeSince
Director/Board Member 63 21/06/2018
Chairman 72 01/01/2004
Director/Board Member 65 05/05/2025
Date Insider Type Main position Quantity % Market Cap.
07-06Sell 865,112 0.6105%
01-02Free

Director

90,000 0.0635%
01-02Free

Chief Technology Officer

300,000 0.2117%
Change 5-day change 1-year change 3-year change Capi.($)
+2.74%-6.11%+51.75%+64.31% 439M
-1.05%+1.39%+3.15%+6.98% 50.61B
+0.48%-2.93%+381.81%+593.44% 39.11B
+0.40%-0.03%+30.00%-5.85% 34.64B
+0.85%-0.82%+21.53%+56.08% 33.79B
-1.31%-1.76%+1.59%+27.01% 26.89B
+0.62%-0.28% - - 16.47B
+1.62%-1.68%+67.66%+120.85% 15.14B
-0.72%+0.12%+14.69%+16.95% 13.85B
+1.54%-0.13%+12.69%-31.57% 12.72B
Average +0.47%-2.61%+64.99%+94.24% 24.37B
Weighted average by Cap. +0.07%-1.16%+80.61%+121.80%

Financials

2026 *2027 *
Net sales 2.5M 3.34M 2.92M 2.7M 4.7M 321M 4.78M 32.21M 12.64M 157M 12.56M 12.28M 541M 3.44M 4.61M 4.03M 3.72M 6.48M 443M 6.6M 44.41M 17.43M 217M 17.32M 16.93M 747M
Net income -50.34M -67.45M -58.94M -54.49M -94.8M -6.48B -96.52M -650M -255M -3.17B -253M -248M -10.92B -84.67M -113M -99.13M -91.64M -159M -10.9B -162M -1.09B -429M -5.34B -426M -417M -18.37B
Net Debt -146M -196M -171M -159M -276M -18.85B -281M -1.89B -742M -9.23B -737M -721M -31.78B -249M -334M -292M -270M -470M -32.1B -478M -3.22B -1.26B -15.72B -1.26B -1.23B -54.12B
Logo Silence Therapeutics plc
Silence Therapeutics plc is a global clinical-stage biotechnology company engaged in transforming people’s lives by silencing diseases through precision-engineered medicines created with proprietary siRNA (short interfering RNA) technology. The Company leverages its mRNAi GOLD platform to create siRNAs designed to precisely target and silence disease-associated genes in the liver. The Company focuses on areas of high unmet medical need with programs advancing cardiovascular disease, hematology and rare diseases. Divesiran (SLN124) is its wholly owned siRNA product candidate designed to inhibit TMPRSS6 expression in the liver. Zerlasiran is a siRNA molecule designed for the treatment of cardiovascular disease associated with elevated Lp(a), a lipoprotein in the blood. In addition to its wholly owned clinical pipeline, it has a third siRNA product candidate from its mRNAi GOLD platform in Phase I development in an undisclosed indication through its collaboration with AstraZeneca.
Employees
88
Date Price Change Volume
14/07/26 $9.470 +1.94% 241,734
13/07/26 $9.290 +2.20% 233,638
10/07/26 $9.090 -7.81% 365,407
09/07/26 $9.860 -0.90% 232,796
08/07/26 $9.950 -1.97% 494,240
Trader
Investor
-
Global
-
Quality
-
ESG MSCI
-
Sell
Consensus
Buy
Mean consensus
BUY
Number of Analysts
7
Last Close Price
9.290USD
Average target price
29.17USD
Spread / Average Target
+213.96%

Quarterly revenue - Rate of surprise