Valuation: Silence Therapeutics plc

Market Cap 383M 516M 451M 417M 724M 49.7B 737M 4.97B 1.95B 24.27B 1.94B 1.89B 83.79B P/E 2026 *
-18.3x
P/E 2027 * -16.3x
Enterprise Value 236M 318M 278M 257M 447M 30.68B 455M 3.07B 1.21B 14.98B 1.2B 1.17B 51.72B EV / Sales 2026 *
94.6x
EV / Sales 2027 * 38.7x
Free-Float
69.36%
Yield 2026 *
-
Yield 2027 * -
1 day+4.50%
1 week+10.75%
Current month-0.55%
1 month+62.74%
3 months+43.68%
6 months+116.67%
Current year+79.61%
1 week 8.91
Extreme 8.91
10.96
1 month 6.52
Extreme 6.52
11.06
Current year 4.19
Extreme 4.19
11.06
1 year 4.19
Extreme 4.19
11.06
3 years 1.97
Extreme 1.97
27.72
5 years 1.97
Extreme 1.97
27.72
10 years 1.97
Extreme 1.97
35
Manager TitleAgeSince
Chief Executive Officer 72 01/12/2025
Director of Finance/CFO 54 01/02/2022
Chief Tech/Sci/R&D Officer - 01/01/2021
Director TitleAgeSince
Director/Board Member 63 21/06/2018
Chairman 72 01/01/2004
Director/Board Member 65 05/05/2025
Date Insider Type Main position Quantity % Market Cap.
7/6/26 A Sell 865,112 0.6105%
1/2/26 A Free

Director

90,000 0.0635%
1/2/26 A Free

Director

90,000 0.0635%
Change 5-day change 1-year change 3-year change Capi.($)
+4.50%+10.75%+71.97%+88.28% 494M
-1.07%-1.27%+0.95%+5.66% 50.35B
-2.85%-6.25%+366.61%+572.09% 39.21B
+1.78%+0.73%+32.68%-4.80% 34.52B
+1.98%+4.82%+13.71%+61.68% 34.6B
+0.06%-0.57%+3.35%+27.42% 27.05B
-3.27%-5.67% - - 16.68B
+1.64%+0.45%+70.86%+121.18% 15.11B
+0.29%+1.02%+14.95%+17.80% 13.85B
-1.21%+0.73%+18.02%-30.96% 13.18B
Average +0.18%+1.18%+65.90%+95.37% 24.5B
Weighted average by Cap. -0.30%+0.43%+77.36%+118.85%

Financials

2026 *2027 *
Net sales 2.5M 3.36M 2.94M 2.72M 4.72M 324M 4.8M 32.43M 12.74M 158M 12.63M 12.36M 547M 3.44M 4.64M 4.05M 3.75M 6.51M 447M 6.63M 44.72M 17.57M 218M 17.42M 17.04M 754M
Net income -50.34M -67.86M -59.32M -54.86M -95.27M -6.54B -96.93M -654M -257M -3.19B -255M -249M -11.02B -84.67M -114M -99.77M -92.27M -160M -11B -163M -1.1B -432M -5.37B -429M -419M -18.54B
Net Debt -146M -197M -173M -160M -277M -19.02B -282M -1.9B -748M -9.29B -741M -725M -32.07B -249M -336M -294M -272M -472M -32.4B -480M -3.24B -1.27B -15.82B -1.26B -1.24B -54.63B
Logo Silence Therapeutics plc
Silence Therapeutics plc is a global clinical-stage biotechnology company engaged in transforming people’s lives by silencing diseases through precision-engineered medicines created with proprietary siRNA (short interfering RNA) technology. The Company leverages its mRNAi GOLD platform to create siRNAs designed to precisely target and silence disease-associated genes in the liver. The Company focuses on areas of high unmet medical need with programs advancing cardiovascular disease, hematology and rare diseases. Divesiran (SLN124) is its wholly owned siRNA product candidate designed to inhibit TMPRSS6 expression in the liver. Zerlasiran is a siRNA molecule designed for the treatment of cardiovascular disease associated with elevated Lp(a), a lipoprotein in the blood. In addition to its wholly owned clinical pipeline, it has a third siRNA product candidate from its mRNAi GOLD platform in Phase I development in an undisclosed indication through its collaboration with AstraZeneca.
Employees
88
Date Price Change Volume
16/07/26 $10.92 +4.50% 567,829
15/07/26 $10.45 +7.18% 791,970
14/07/26 $9.750 +4.95% 338,977
13/07/26 $9.290 +2.20% 233,638
10/07/26 $9.090 -7.81% 365,407
Trader
Investor
-
Global
-
Quality
-
ESG MSCI
-
Sell
Consensus
Buy
Mean consensus
BUY
Number of Analysts
7
Last Close Price
10.92USD
Average target price
29.17USD
Spread / Average Target
+167.09%

Quarterly revenue - Rate of surprise