Valuation: Silence Therapeutics plc

Market Cap 410M 546M 479M 446M 769M 52.12B 782M 5.29B 2.07B 25.85B 2.05B 2B 89.31B P/E 2026 *
-19.3x
P/E 2027 * -17.2x
Enterprise Value 264M 351M 308M 287M 495M 33.58B 504M 3.41B 1.33B 16.65B 1.32B 1.29B 57.53B EV / Sales 2026 *
105x
EV / Sales 2027 * 46.5x
Free-Float
69.36%
Yield 2026 *
-
Yield 2027 * -
1 day-2.77%
1 week-5.49%
Current month+1.82%
1 month+3.61%
3 months+57.24%
6 months+125.40%
Current year+83.88%
1 week 10.55
Extreme 10.55
12.19
1 month 8.91
Extreme 8.91
12.19
Current year 4.19
Extreme 4.19
12.19
1 year 4.19
Extreme 4.19
12.19
3 years 1.97
Extreme 1.97
27.72
5 years 1.97
Extreme 1.97
27.72
10 years 1.97
Extreme 1.97
35
Manager TitleAgeSince
Chief Executive Officer 72 01/12/2025
Director of Finance/CFO 54 01/02/2022
Chief Tech/Sci/R&D Officer - 01/01/2021
Director TitleAgeSince
Director/Board Member 63 21/06/2018
Chairman 72 01/01/2004
Director/Board Member 65 05/05/2025
Date Insider Type Main position Quantity % Market Cap.
7/6/26 A Sell 865,112 0.6105%
1/2/26 A Free

Director

90,000 0.0635%
1/2/26 A Free

Director

90,000 0.0635%
Change 5-day change 1-year change 3-year change Capi.($)
-2.68%-5.49%+80.32%+87.58% 546M
+2.09%+6.56%-1.48%+13.14% 47.88B
-1.72%-1.00%+389.58%+590.27% 39.09B
-0.94%+2.08%+6.82%+52.46% 36.75B
+1.02%+24.06%+26.59%+10.07% 40.55B
+1.47%+4.90%+6.48%+43.52% 27.96B
+0.04%+1.25% - - 16.77B
+1.01%+8.21%+27.59%+125.73% 15.94B
+0.06%-2.81%+3.16%+9.62% 13.55B
-1.18%+5.65%-4.58%-29.70% 13.81B
Average +0.03%+4.84%+59.39%+100.30% 25.28B
Weighted average by Cap. +0.41%+5.06%+72.57%+122.96%

Financials

2026 *2027 *
Net sales 2.51M 3.34M 2.93M 2.73M 4.71M 319M 4.79M 32.42M 12.69M 158M 12.55M 12.28M 547M 3.47M 4.61M 4.05M 3.77M 6.5M 441M 6.61M 44.74M 17.51M 219M 17.32M 16.95M 755M
Net income -50.4M -67.06M -58.85M -54.8M -94.49M -6.41B -96.11M -650M -254M -3.18B -252M -246M -10.98B -84.8M -113M -99.01M -92.2M -159M -10.78B -162M -1.09B -428M -5.35B -424M -414M -18.47B
Net Debt -146M -194M -170M -159M -273M -18.54B -278M -1.88B -737M -9.2B -729M -713M -31.77B -249M -331M -290M -270M -466M -31.62B -474M -3.21B -1.26B -15.68B -1.24B -1.22B -54.18B
Logo Silence Therapeutics plc
Silence Therapeutics plc is a global clinical-stage biotechnology company engaged in transforming people’s lives by silencing diseases through precision-engineered medicines created with proprietary siRNA (short interfering RNA) technology. The Company leverages its mRNAi GOLD platform to create siRNAs designed to precisely target and silence disease-associated genes in the liver. The Company focuses on areas of high unmet medical need with programs advancing cardiovascular disease, hematology and rare diseases. Divesiran (SLN124) is its wholly owned siRNA product candidate designed to inhibit TMPRSS6 expression in the liver. Zerlasiran is a siRNA molecule designed for the treatment of cardiovascular disease associated with elevated Lp(a), a lipoprotein in the blood. In addition to its wholly owned clinical pipeline, it has a third siRNA product candidate from its mRNAi GOLD platform in Phase I development in an undisclosed indication through its collaboration with AstraZeneca.
Employees
88
Date Price Change Volume
29/07/26 $11.20 -3.03% 100,951
28/07/26 $11.55 -4.31% 1,190,811
27/07/26 $12.07 +9.53% 666,332
24/07/26 $11.02 -3.76% 341,873
23/07/26 $11.45 -3.21% 480,128
Trader
Investor
-
Global
-
Quality
-
ESG MSCI
-
Sell
Consensus
Buy
Mean consensus
BUY
Number of Analysts
7
Last Close Price
11.55USD
Average target price
29.17USD
Spread / Average Target
+152.53%

Quarterly revenue - Rate of surprise