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Valuation: ISIS Pharmaceuticals, Inc.

Market Cap 12.11B 10.45B 9.62B 9.03B 16.94B 1,147B 17.13B 114B 44.38B 560B 45.44B 44.47B 1,941B P/E Ratio 2026 *
-20.3x
P/E Ratio 2027 * -57x
Enterprise Value 11.89B 10.26B 9.45B 8.86B 16.63B 1,126B 16.81B 112B 43.56B 550B 44.61B 43.66B 1,905B EV / Sales 2026 *
13.4x
EV / Sales 2027 * 8.02x
Free-Float
99.08%
Yield 2026 *
-
Yield 2027 * -
Manager TitleAgeSince
Investor Relations Contact 60 01/07/2012
Chief Executive Officer 64 01/01/2020
Director of Finance/CFO 64 01/05/2000
Director TitleAgeSince
Director/Board Member 64 13/12/2005
Director/Board Member 73 01/05/2002
Director/Board Member 64 25/03/2019
Change 5-day change 1-year change 3-year change Capi.($)
+1.33%+2.73% - - 12.11B
+0.96%+1.94%-12.97%-13.01% 43.03B
+4.02%+7.26%+294.33%+533.90% 32.71B
-1.69%-2.76%+13.70%-16.14% 30.29B
+1.41%-0.70%-0.53%+28.87% 29.4B
+1.16%+2.10%+14.27%+22.05% 25.08B
+2.40%+6.10% - - 13.54B
+0.03%+2.92%+56.75%+114.15% 13.35B
-1.09%-2.37%+5.07%+5.25% 12.97B
+1.05%-1.16%+1.41%-35.92% 11.19B
Average +0.49%+0.76%+46.50%+79.89% 23.51B
Weighted average by Cap. +0.38%+0.80%+53.87%+95.99%

Financials

2026 *2027 *
Net sales 890M 768M 707M 664M 1.25B 84.31B 1.26B 8.36B 3.26B 41.18B 3.34B 3.27B 143B 1.49B 1.29B 1.19B 1.11B 2.09B 142B 2.11B 14.04B 5.48B 69.13B 5.61B 5.49B 240B
Net income -595M -513M -472M -443M -832M -56.31B -841M -5.59B -2.18B -27.51B -2.23B -2.18B -95.31B -215M -185M -171M -160M -301M -20.35B -304M -2.02B -788M -9.94B -806M -789M -34.45B
Net Debt -222M -191M -176M -165M -310M -21.01B -314M -2.08B -813M -10.26B -832M -815M -35.55B -130M -112M -103M -97.09M -182M -12.33B -184M -1.22B -477M -6.02B -489M -478M -20.87B
Logo ISIS Pharmaceuticals, Inc.
Ionis Pharmaceuticals, Inc. develops six marketed medicines for serious diseases, including medicines for neurologic and cardiovascular diseases. Its marketed medicines consist of TRYNGOLZA, WAINUA (eplontersen), SPINRAZA (nusinersen), QALSODY (tofersen), TEGSEDI (inotersen) and WAYLIVRA (volanesorsen). TRYNGOLZA reduces triglyceride levels in adults with familial chylomicronemia syndrome (FCS). WAINUA is approved for the treatment of the polyneuropathy of hereditary transthyretin-medicated amyloidosis (ATTRv-PN) in adults. SPINRAZA is used for the treatment of pediatric and adult patients with spinal muscular atrophy. QALSODY is approved for the treatment of Amyotrophic Lateral Sclerosis in adults who have a mutation in the superoxide dismutase 1 (SOD1) gene, or SOD1-ALS. TEGSEDI is approved for the treatment of ATTRv-PN in adults. WAYLIVRA is approved as an adjunct to diet in adult patients with genetically confirmed FCS and at high risk of acute, potentially fatal pancreatitis.
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