Valuation: ISIS Pharmaceuticals, Inc.

Market Cap 4.55B 4.12B 3.81B 3.44B 6.48B 429B 6.71B 45.8B 18.16B 229B 17.07B 16.71B 727B P/E 2026 *
-8.04x
P/E 2027 * -10.2x
Enterprise Value 4.44B 4.03B 3.72B 3.36B 6.33B 419B 6.56B 44.74B 17.74B 224B 16.68B 16.32B 710B EV / Sales 2026 *
4.85x
EV / Sales 2027 * 3.85x
Free-Float
99.07%
Yield 2026 *
-
Yield 2027 * -
Manager TitleAgeSince
Investor Relations Contact 60 01/07/2012
Chief Executive Officer 64 01/01/2020
Director of Finance/CFO 64 01/05/2000
Director TitleAgeSince
Director/Board Member 64 13/12/2005
Director/Board Member 73 01/05/2002
Director/Board Member 64 25/03/2019
Change 5-day change 1-year change 3-year change Capi.($)
+1.33%+2.73% - - 4.55B
-2.69%-5.28%+58.42%+65.89% 68.45B
-0.92%+7.70%+12.90%+93.35% 61.31B
0.00%-0.95%+20.09%+99.04% 55.73B
+0.12%+2.25%+12.97%+109.26% 47.51B
-1.67%-1.91%+19.27%+37.67% 44.68B
-2.21%-9.82%+169.34%+782.44% 38.14B
+2.15%-0.47%+22.85%+56.09% 35.85B
-2.32%-5.14%+75.43%+60.15% 33.05B
+2.56%+6.02%-36.48%+407.49% 25.9B
Average -0.33%+2.41%+39.42%+190.16% 46B
Weighted average by Cap. -0.73%+2.25%+39.48%+163.23%

Financials

2026 *2027 *
Net sales 916M 831M 768M 693M 1.31B 86.41B 1.35B 9.23B 3.66B 46.16B 3.44B 3.37B 147B 1.22B 1.11B 1.03B 926M 1.74B 115B 1.81B 12.32B 4.89B 61.65B 4.59B 4.5B 196B
Net income -562M -510M -471M -425M -801M -53.02B -830M -5.66B -2.25B -28.32B -2.11B -2.07B -89.91B -439M -398M -368M -332M -625M -41.37B -647M -4.42B -1.75B -22.1B -1.65B -1.61B -70.15B
Net Debt -105M -94.99M -87.86M -79.28M -149M -9.88B -155M -1.06B -419M -5.28B -393M -385M -16.76B 163M 148M 137M 124M 233M 15.41B 241M 1.65B 653M 8.23B 613M 600M 26.13B
Logo ISIS Pharmaceuticals, Inc.
Ionis Pharmaceuticals, Inc. develops six marketed medicines for serious diseases, including medicines for neurologic and cardiovascular diseases. Its marketed medicines consist of TRYNGOLZA, WAINUA (eplontersen), SPINRAZA (nusinersen), QALSODY (tofersen), TEGSEDI (inotersen) and WAYLIVRA (volanesorsen). TRYNGOLZA reduces triglyceride levels in adults with familial chylomicronemia syndrome (FCS). WAINUA is approved for the treatment of the polyneuropathy of hereditary transthyretin-medicated amyloidosis (ATTRv-PN) in adults. SPINRAZA is used for the treatment of pediatric and adult patients with spinal muscular atrophy. QALSODY is approved for the treatment of Amyotrophic Lateral Sclerosis in adults who have a mutation in the superoxide dismutase 1 (SOD1) gene, or SOD1-ALS. TEGSEDI is approved for the treatment of ATTRv-PN in adults. WAYLIVRA is approved as an adjunct to diet in adult patients with genetically confirmed FCS and at high risk of acute, potentially fatal pancreatitis.
Employees
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Trader
Investor
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Global
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Quality
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ESG MSCI
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MarketScreener Ratings - ISIS Pharmaceuticals, Inc.