Valuation: Ionis Pharmaceuticals, Inc.

Market Cap 6.55B 5.88B 5.37B 4.9B 9.24B 616B 9.53B 64.72B 25.81B 329B 24.59B 24.06B 1,037B P/E 2026 *
-11.1x
P/E 2027 * -20.2x
Enterprise Value 6.45B 5.78B 5.29B 4.82B 9.09B 606B 9.38B 63.71B 25.4B 323B 24.2B 23.68B 1,021B EV / Sales 2026 *
6.99x
EV / Sales 2027 * 4.87x
Free-Float
99.06%
Yield 2026 *
-
Yield 2027 * -
1 day+1.60%
1 week-9.42%
Current month-9.42%
1 month-10.73%
3 months-30.30%
6 months-48.15%
Current year-50.17%
1 week 38.3
Extreme 38.305
43.91
1 month 38.3
Extreme 38.305
45.84
Current year 38.3
Extreme 38.305
86.74
1 year 38.3
Extreme 38.305
86.74
3 years 23.95
Extreme 23.95
86.74
5 years 23.95
Extreme 23.95
86.74
10 years 23.95
Extreme 23.95
86.74
Manager TitleAgeSince
Investor Relations Contact 60 01/07/2012
Chief Executive Officer 64 01/01/2020
Director of Finance/CFO 64 01/05/2000
Director TitleAgeSince
Director/Board Member 64 13/12/2005
Director/Board Member 73 01/05/2002
Director/Board Member 64 25/03/2019
Date Insider Type Main position Quantity % Market Cap. Importance
8/31/26 A Others

Chief Technology Officer

110 0.0001%
8/31/26 A Others

Executive/Senior Manager

58 0.0000%
8/31/26 A Others

Founder

98 0.0001%
Change 5-day change 1-year change 3-year change Capi.($)
+1.60%-9.42%-46.40%-17.38% 6.55B
-4.83%+3.51%+55.00%+63.79% 66.7B
+0.02%+1.07%+11.72%+75.63% 56.88B
-1.34%+2.98%+25.08%+100.18% 56.53B
+5.09%+9.89%+27.19%+105.85% 46.49B
+2.62%+1.68%+29.16%+35.86% 44.8B
+8.24%+0.51%+215.16%+794.74% 41.59B
-1.86%+10.13%+28.14%+55.48% 35.35B
-2.97%-9.84%+90.91%+73.49% 33.29B
+5.19%+1.62%-39.69%+368.87% 25.1B
Average +1.18%+1.44%+39.63%+165.65% 41.33B
Weighted average by Cap. +0.67%+2.88%+48.38%+162.97%

Financials

2026 *2027 *
Net sales 922M 827M 756M 690M 1.3B 86.71B 1.34B 9.11B 3.63B 46.26B 3.46B 3.39B 146B 1.36B 1.22B 1.11B 1.02B 1.92B 128B 1.98B 13.44B 5.36B 68.21B 5.1B 4.99B 215B
Net income -579M -520M -475M -434M -817M -54.46B -842M -5.72B -2.28B -29.06B -2.17B -2.13B -91.74B -327M -294M -268M -245M -461M -30.77B -476M -3.23B -1.29B -16.42B -1.23B -1.2B -51.83B
Net Debt -103M -92.37M -84.42M -77.06M -145M -9.68B -150M -1.02B -406M -5.17B -387M -378M -16.31B 68.31M 61.27M 55.99M 51.11M 96.3M 6.42B 99.33M 675M 269M 3.43B 256M 251M 10.82B
Projected Income Statement - Annual - Ionis Pharmaceuticals, Inc.
Logo Ionis Pharmaceuticals, Inc.
Ionis Pharmaceuticals, Inc. develops six marketed medicines for serious diseases, including medicines for neurologic and cardiovascular diseases. Its marketed medicines consist of TRYNGOLZA, WAINUA (eplontersen), SPINRAZA (nusinersen), QALSODY (tofersen), TEGSEDI (inotersen) and WAYLIVRA (volanesorsen). TRYNGOLZA reduces triglyceride levels in adults with familial chylomicronemia syndrome (FCS). WAINUA is approved for the treatment of the polyneuropathy of hereditary transthyretin-medicated amyloidosis (ATTRv-PN) in adults. SPINRAZA is used for the treatment of pediatric and adult patients with spinal muscular atrophy. QALSODY is approved for the treatment of Amyotrophic Lateral Sclerosis in adults who have a mutation in the superoxide dismutase 1 (SOD1) gene, or SOD1-ALS. TEGSEDI is approved for the treatment of ATTRv-PN in adults. WAYLIVRA is approved as an adjunct to diet in adult patients with genetically confirmed FCS and at high risk of acute, potentially fatal pancreatitis.
Employees
1,480
Date Price Change Volume
06/11/26 $39.42 +1.60% 2,911,840
05/11/26 $38.80 -3.36% 2,975,955
04/11/26 $40.15 -0.67% 4,102,754
03/11/26 $40.42 -1.99% 4,006,909
02/11/26 $41.24 -5.24% 2,559,959
Trader
Investor
-
Global
-
Quality
-
ESG MSCI
A
MarketScreener Ratings - Ionis Pharmaceuticals, Inc.
Sell
Consensus
Buy
Mean consensus
BUY
Number of Analysts
25
Last Close Price
39.42USD
Average target price
84.13USD
Spread / Average Target
+113.42%

Quarterly revenue - Rate of surprise

Rate of surprise - Net sales - Quarterly - Ionis Pharmaceuticals, Inc.
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