Valuation: Ionis Pharmaceuticals, Inc.

Market Cap 4.72B 4.27B 3.94B 3.56B 6.73B 444B 6.93B 47.25B 18.78B 237B 17.71B 17.33B 754B P/E 2026 *
-8.34x
P/E 2027 * -10.6x
Enterprise Value 4.61B 4.17B 3.85B 3.49B 6.58B 434B 6.78B 46.2B 18.37B 232B 17.31B 16.94B 737B EV / Sales 2026 *
5.03x
EV / Sales 2027 * 4.02x
Free-Float
99.07%
Yield 2026 *
-
Yield 2027 * -
1 day-3.60%
1 week-31.98%
Current month-37.25%
1 month-39.69%
3 months-50.72%
6 months-63.77%
Current year-65.48%
1 week 27.28
Extreme 27.282
40
1 month 27.28
Extreme 27.282
45.84
Current year 27.28
Extreme 27.282
86.74
1 year 27.28
Extreme 27.282
86.74
3 years 23.95
Extreme 23.95
86.74
5 years 23.95
Extreme 23.95
86.74
10 years 23.95
Extreme 23.95
86.74
Manager TitleAgeSince
Investor Relations Contact 60 01/07/2012
Chief Executive Officer 64 01/01/2020
Director of Finance/CFO 64 01/05/2000
Director TitleAgeSince
Director/Board Member 64 13/12/2005
Director/Board Member 73 01/05/2002
Director/Board Member 64 25/03/2019
Date Insider Type Main position Quantity % Market Cap. Importance
10/16/26 A Sell

Executive/Senior Manager

-53 0.0000%
10/16/26 A Sell

Head of Human Resources

-1,357 0.0008%
8/31/26 A Others

Chief Technology Officer

110 0.0001%
Change 5-day change 1-year change 3-year change Capi.($)
-3.60%-31.98%-62.31%-41.09% 4.72B
+1.10%+1.03%+62.53%+70.47% 67.53B
+1.28%+8.79%+16.26%+95.16% 60.74B
+0.36%+0.67%+20.48%+99.04% 55.66B
-0.96%+10.11%+21.04%+108.91% 47.97B
-1.25%+2.77%+24.06%+38.34% 45.24B
-2.41%-11.69%+175.20%+794.72% 39.08B
+1.21%+4.75%+27.30%+52.81% 35.34B
-0.87%-1.34%+83.95%+63.96% 33.45B
-2.22%+7.34%-39.04%+397.14% 26.49B
Average -0.74%-0.52%+32.95%+167.95% 42B
Weighted average by Cap. -0.21%+2.52%+42.62%+164.34%

Financials

2026 *2027 *
Net sales 916M 829M 766M 692M 1.31B 86.19B 1.35B 9.18B 3.65B 46.1B 3.44B 3.37B 146B 1.22B 1.11B 1.02B 925M 1.74B 115B 1.8B 12.26B 4.87B 61.57B 4.59B 4.5B 196B
Net income -562M -509M -470M -425M -802M -52.88B -826M -5.63B -2.24B -28.29B -2.11B -2.07B -89.89B -439M -397M -367M -332M -625M -41.26B -645M -4.39B -1.75B -22.07B -1.65B -1.61B -70.14B
Net Debt -105M -94.83M -87.58M -79.2M -149M -9.86B -154M -1.05B -417M -5.27B -393M -385M -16.76B 198M 179M 165M 150M 282M 18.63B 291M 1.98B 789M 9.97B 743M 728M 31.66B
Projected Income Statement - Annual - Ionis Pharmaceuticals, Inc.
Logo Ionis Pharmaceuticals, Inc.
Ionis Pharmaceuticals, Inc. develops six marketed medicines for serious diseases, including medicines for neurologic and cardiovascular diseases. Its marketed medicines consist of TRYNGOLZA, WAINUA (eplontersen), SPINRAZA (nusinersen), QALSODY (tofersen), TEGSEDI (inotersen) and WAYLIVRA (volanesorsen). TRYNGOLZA reduces triglyceride levels in adults with familial chylomicronemia syndrome (FCS). WAINUA is approved for the treatment of the polyneuropathy of hereditary transthyretin-medicated amyloidosis (ATTRv-PN) in adults. SPINRAZA is used for the treatment of pediatric and adult patients with spinal muscular atrophy. QALSODY is approved for the treatment of Amyotrophic Lateral Sclerosis in adults who have a mutation in the superoxide dismutase 1 (SOD1) gene, or SOD1-ALS. TEGSEDI is approved for the treatment of ATTRv-PN in adults. WAYLIVRA is approved as an adjunct to diet in adult patients with genetically confirmed FCS and at high risk of acute, potentially fatal pancreatitis.
Employees
1,485
Date Price Change Volume
12/11/26 $27.31 -3.60% 6,195,671
11/11/26 $28.33 +0.50% 6,552,104
10/11/26 $28.19 -9.06% 10,692,785
09/11/26 $31.00 -21.36% 19,508,605
06/11/26 $39.42 +1.60% 2,911,840
Trader
Investor
-
Global
-
Quality
-
ESG MSCI
A
MarketScreener Ratings - Ionis Pharmaceuticals, Inc.
Sell
Consensus
Buy
Mean consensus
BUY
Number of Analysts
25
Last Close Price
28.33USD
Average target price
69.30USD
Spread / Average Target
+144.63%
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