Valuation: Septerna, Inc.

Market Cap 1.58B 1.37B 1.28B 1.17B 2.21B 150B 2.25B 15.09B 5.91B 74.95B 5.92B 5.79B 247B P/E 2026 *
-20.2x
P/E 2027 * -14.4x
Enterprise Value 1.23B 1.07B 996M 915M 1.72B 117B 1.75B 11.75B 4.6B 58.36B 4.61B 4.51B 192B EV / Sales 2026 *
16x
EV / Sales 2027 * 16.2x
Free-Float
97.17%
Yield 2026 *
-
Yield 2027 * -
1 day+1.54%
1 week+4.45%
Current month+1.54%
1 month+2.88%
3 months+48.16%
6 months+36.96%
Current year+25.47%
1 week 33.19
Extreme 33.19
35.82
1 month 30.55
Extreme 30.55
38.04
Current year 22.78
Extreme 22.78
38.04
1 year 10.62
Extreme 10.6161
38.04
3 years 4.17
Extreme 4.17
38.04
5 years 4.17
Extreme 4.17
38.04
10 years 4.17
Extreme 4.17
38.04
Manager TitleAgeSince
Chief Executive Officer 60 01/11/2021
Director of Finance/CFO 55 06/01/2025
President 58 01/08/2025
Director TitleAgeSince
Director/Board Member 60 01/11/2021
Chairman 50 01/11/2021
Director/Board Member 41 01/11/2021
Date Insider Type Main position Quantity % Market Cap.
7/15/26 A Fiscal year

Chairperson

12,000 0.0266%
7/1/26 A Fiscal year

Executive/Senior Manager

9,999 0.0222%
6/29/26 A Fiscal year

Head of Human Resources

6,534 0.0145%
Change 5-day change 1-year change 3-year change Capi.($)
+1.54%+4.45%+186.49% - 1.58B
+0.46%+0.29%-0.67%+13.96% 48.22B
-2.71%-2.99%+398.09%+472.12% 38.79B
-0.71%+9.45%+27.90%+7.89% 38.41B
-0.71%-3.72%+4.94%+52.45% 34.88B
-2.41%+1.96%+11.68%+38.17% 29.19B
-0.66%-2.73%+35.50%+122.17% 16B
-0.19%-3.93% - - 16.05B
+1.56%+0.44%+3.43%+16.80% 13.53B
-3.15%-6.14%-4.82%-36.90% 12.22B
Average -0.28%-0.15%+73.61%+85.83% 24.89B
Weighted average by Cap. -0.29%+0.18%+76.64%+103.63%

Financials

2026 *2027 *
Net sales 76.91M 66.85M 62.41M 57.29M 108M 7.33B 110M 736M 288M 3.66B 289M 283M 12.06B 65.83M 57.22M 53.42M 49.04M 92.46M 6.27B 94.08M 630M 247M 3.13B 247M 242M 10.32B
Net income -68.86M -59.84M -55.87M -51.29M -96.71M -6.56B -98.4M -659M -258M -3.27B -259M -253M -10.8B -122M -106M -99.36M -91.21M -172M -11.67B -175M -1.17B -459M -5.82B -460M -450M -19.2B
Net Debt -349M -303M -283M -260M -490M -33.26B -499M -3.34B -1.31B -16.58B -1.31B -1.28B -54.7B -508M -442M -413M -379M -714M -48.46B -727M -4.86B -1.91B -24.17B -1.91B -1.87B -79.71B
Logo Septerna, Inc.
Septerna, Inc. is a clinical-stage biotechnology company. The Company is developing G protein-coupled receptor (GPCR) oral small-molecule drug discovery powered by its proprietary Native Complex Platform. Its pipeline of product candidates is focused on treating patients in three therapeutic areas: endocrinology, immunology and inflammation, and metabolic diseases. Its industrial-scale Native Complex Platform is designed to target certain GPCRs for the first time, uncover novel binding pockets for validated receptors, and pursue a wide spectrum of pharmacologies, including agonists, antagonists, and allosteric modulators, to achieve desired therapeutic effects. It is advancing a deep portfolio of oral small molecule GPCR-targeted programs with novel mechanistic approaches to treat diseases across multiple therapeutic areas for patients with unmet needs. It is focused on therapeutic areas, such as neurology, women’s health, cardiovascular, and respiratory disease.
Employees
130
Date Price Change Volume
03/08/26 $34.98 +1.54% 201,795
31/07/26 $34.45 -2.08% 241,095
30/07/26 $35.18 +4.67% 266,084
29/07/26 $33.61 -1.06% 158,216
28/07/26 $33.97 +1.43% 263,368
Trader
Investor
-
Global
-
Quality
-
ESG MSCI
BB
Sell
Consensus
Buy
Mean consensus
BUY
Number of Analysts
10
Last Close Price
34.98USD
Average target price
45.00USD
Spread / Average Target
+28.64%

Quarterly revenue - Rate of surprise

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