Valuation: Karyopharm Therapeutics Inc.

Market Cap 227M 198M 183M 169M 319M 21.79B 325M 2.19B 857M 10.67B 852M 833M 36.74B P/E 2026 *
-2.4x
P/E 2027 * -3.23x
Enterprise Value 480M 419M 388M 358M 674M 46.09B 687M 4.62B 1.81B 22.57B 1.8B 1.76B 77.71B EV / Sales 2026 *
3.5x
EV / Sales 2027 * 1.46x
Free-Float
95.32%
Yield 2026 *
-
Yield 2027 * -

Last Transcript: Karyopharm Therapeutics Inc.

1 day-4.40%
1 week-9.84%
Current month-1.54%
1 month-0.21%
3 months+12.38%
6 months+44.44%
Current year+30.71%
1 week 9.52
Extreme 9.52
10.76
1 month 8.78
Extreme 8.78
10.86
Current year 5
Extreme 5
10.99
1 year 3.65
Extreme 3.6503
10.99
3 years 3.51
Extreme 3.51
29.25
5 years 3.51
Extreme 3.51
220.95
10 years 3.51
Extreme 3.51
444.15
Manager TitleAgeSince
Chief Executive Officer 58 03/05/2021
Director of Finance/CFO 55 03/01/2025
Chief Tech/Sci/R&D Officer - 01/04/2023
Director TitleAgeSince
Director/Board Member 62 01/01/2013
Director/Board Member 61 01/04/2013
Director/Board Member 78 03/10/2013
Date Insider Type Main position Quantity % Market Cap.
05-21Free

Director

15,508 0.0688%
05-21Free

Director

15,508 0.0688%
05-21Free

Director

15,508 0.0688%
Change 5-day change 1-year change 3-year change Capi.($)
-4.50%-9.84%+126.89%-58.08% 227M
+1.33%+0.02%+21.00%-8.12% 66.75B
+1.29%-5.31%+37.96%+193.79% 50.65B
+1.10%+38.30%+38.30%+38.30% 42.55B
-0.98%-1.79%-49.61%-53.35% 41.15B
+1.50%-3.34%+51.90%-30.43% 28.34B
-0.53%-9.19%+112.22%-45.33% 26.76B
-0.03%-2.50%+67.52%+87.18% 22.95B
+7.77%+11.30%+18.35%+199.08% 20B
-2.01%+5.50%+75.95%+157.91% 16.48B
Average +0.49%-2.18%+50.05%+48.09% 31.59B
Weighted average by Cap. +0.96%-2.97%+33.51%+48.13%

Financials

2026 *2027 *
Net sales 137M 120M 111M 102M 193M 13.18B 196M 1.32B 519M 6.45B 515M 504M 22.22B 155M 136M 125M 116M 218M 14.92B 222M 1.5B 587M 7.3B 583M 570M 25.15B
Net income -121M -106M -97.77M -90.33M -170M -11.62B -173M -1.17B -457M -5.69B -455M -445M -19.6B -135M -118M -109M -100M -189M -12.92B -193M -1.3B -509M -6.33B -505M -494M -21.79B
Net Debt 253M 221M 204M 189M 356M 24.3B 362M 2.44B 956M 11.9B 950M 929M 40.97B -
Logo Karyopharm Therapeutics Inc.
Karyopharm Therapeutics Inc. is a commercial-stage pharmaceutical company. The Company is engaged in the discovery, development and commercialization of drugs directed against nuclear export for the treatment of cancer. It is developing and commercializing novel, small molecule XPO1 inhibitor compounds that inhibit the nuclear export protein exportin 1 (XPO1). Its lead asset, XPOVIO (selinexor), is marketed in combination with bortezomib and dexamethasone for the treatment of adult patients with multiple myeloma who have received at least one prior therapy. XPOVIO is also marketed for treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL). The Company is engaged in evaluating selinexor in certain hematological and solid tumor malignancies, including myelofibrosis, endometrial cancer and multiple myeloma. The Company’s product candidate, eltanexor, is an oral SINE compound like selinexor, that selectively blocks the nuclear export protein XPO1.
Employees
228
Date Price Change Volume
15/07/26 $9.585 -4.25% 97,970
14/07/26 $10.01 -0.40% 481,544
13/07/26 $10.05 -2.80% 431,397
10/07/26 $10.34 +1.37% 320,246
09/07/26 $10.20 -4.40% 281,109
Trader
Investor
-
Global
-
Quality
-
ESG MSCI
-
Sell
Consensus
Buy
Mean consensus
BUY
Number of Analysts
7
Last Close Price
10.01USD
Average target price
13.50USD
Spread / Average Target
+34.87%

Quarterly revenue - Rate of surprise

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