Valuation: Centessa Pharmaceuticals plc

Market Cap 6.27B 5.49B 5.06B 4.74B 8.89B 591B 9.08B 60.87B 23.55B 292B 23.53B 23.02B 1,013B P/E 2026 *
-26x
P/E 2027 * -22.6x
Enterprise Value 6.27B 5.49B 5.06B 4.74B 8.89B 591B 9.08B 60.87B 23.55B 292B 23.53B 23.02B 1,013B EV / Sales 2026 *
-
EV / Sales 2027 * -
Free-Float
78.43%
Yield 2026 *
-
Yield 2027 * -
1 day+0.80%
1 week+1.20%
Current month+1.86%
1 month+1.81%
3 months+37.76%
6 months+59.89%
Current year+61.94%
1 week 39.98
Extreme 39.98
40.56
1 month 39.58
Extreme 39.58
40.56
Current year 21.5
Extreme 21.5
40.56
1 year 12.78
Extreme 12.78
40.56
3 years 5.15
Extreme 5.15
40.56
5 years 2.88
Extreme 2.885
40.56
10 years 2.88
Extreme 2.885
40.56
Manager TitleAgeSince
Chief Tech/Sci/R&D Officer - 01/10/2024
Chief Tech/Sci/R&D Officer 55 01/03/2023
Chief Administrative Officer 58 01/04/2021
Director TitleAgeSince
Director/Board Member - 24/06/2026
Director/Board Member - 24/06/2026
Date Insider Type Main position Quantity % Market Cap.
06-24Issuer sale

Compliance Officer

-1,376,483 0.8896%
06-24Issuer sale

Director

-711,155 0.4596%
06-24Issuer sale

Director

-392,474 0.2537%
Change 5-day change 1-year change 3-year change Capi.($)
+0.80%+1.20%+210.58%+486.96% 6.27B
-0.48%+7.20%-5.08%+2.45% 46.2B
+2.19%+11.71%+385.81%+632.13% 38.71B
+2.53%+13.93%+20.85%-10.61% 31.9B
+1.65%+3.61%+9.98%+55.42% 31.12B
-4.16%-2.58%+8.74%+15.22% 23.77B
-0.32%+12.96% - - 16.2B
+1.37%+14.53%+71.80%+134.14% 15.05B
+1.00%+10.30%+13.31%+22.84% 13.74B
+3.63%+9.53%+104.07%+107.62% 13.42B
Average +0.82%+8.41%+91.12%+160.68% 23.64B
Weighted average by Cap. +0.76%+8.53%+90.21%+150.60%

Financials

2026 *2027 *
Net sales - -
Net income -237M -208M -192M -180M -337M -22.39B -344M -2.31B -892M -11.06B -891M -872M -38.37B -265M -233M -215M -201M -377M -25.04B -384M -2.58B -998M -12.38B -997M -975M -42.91B
Net Debt - -
Logo Centessa Pharmaceuticals plc
Centessa Pharmaceuticals plc is a clinical-stage pharmaceutical company. The Company is developing a new class of potential therapies within its orexin receptor 2 (OX2R) agonist program for the treatment of excessive daytime sleepiness (EDS), impaired attention, cognitive deficits, fatigue and other symptoms across neurological, neurodegenerative and neuropsychiatric disorders. It also has an early-stage immuno-oncology program focused on its LockBody technology platform. Its OX2R agonist pipeline includes ORX750, its advanced OX2R agonist development candidate, and ORX142, ORX489 and OX2R agonists in preclinical development. Its ORX750, an investigational, orally administered, highly potent and selective OX2R agonist, is in a Phase IIa study of participants with narcolepsy type 1 (NT1), NT2 and idiopathic hypersomnia (IH). ORX142 is the second OX2R agonist development candidate being advanced for the treatment of neurological and neurodegenerative disorders and other symptoms.
Employees
129
Date Price Change Volume
23/06/26 $40.50 +0.80% 11,330,436
22/06/26 $40.18 +0.40% 3,758,569
18/06/26 $40.02 +0.38% 5,588,743
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